This timely, concise title provides an important update on clinical lipid management. Using information from recent clinical trials and in special populations, the book begins by offering an easy-to-read overview of LDL, HDL, and triglyceride metabolism and the genetics of lipid disorders. The link between inflammation and lipids, and how this relates to atherosclerosis development, is also addressed, as are the measures of subclinical atherosclerosis in patients with abnormal lipid levels. Lipid abnormalities in children, with a particular focus on vulnerable populations (with an emphasis on ethnicity and childhood obesity), are covered. The treatment goals and approaches for managing lipids in the clinic are thoroughly discussed, emphasizing the important role of statin use and addressing controversies of lipid management in special populations such as heart failure, end stage kidney disease and fatty liver disease. Of special note, an important update on how new HIV medications impact lipid levels is provided. In all, Lipid Management: From Basics to Clinic, is an invaluable, handy resource for understanding changes in lipids in different populations and for sharpening the clinical approach to managing complicated lipid cases.
Basics of Lipoprotein Metabolism.- Genetics of Lipid Disorders.- Lipid and Inflammation in Atherosclerosis.- Dyslipidemia: Relationship to Insulin Resistance, Fatty Liver, and Sub-clinical atherosclerosis.- Is low HDL cholesterol a marker of a mediator of cardiovascular disease?.- Approach to the patient with lipid disorders.- The Effects of Diet in Hyperlipidemia.- Statins.- Non-alcoholic Fatty Liver Disease (NAFLD): The Lipid Disease of the Liver and the Effect of Statins.- Statins in Heart Failure.- Statins in Chronic Kidney Disease.- Non-statin therapies.- LDL Apheresis.- Dyslipidemia in HIV.- New and Emerging Lipid Therapies.
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